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"Organic, Inc. is an interactive advertising agency headquartered in New York City with additional offices in Detroit, Los Angeles and San Francisco and is a part of the Omnicom Group Inc. History One of the original interactive agencies, Organic was founded by Jonathan Nelson, Brian Behlendorf, Cliff Skolnick and Matthew Nelson in 1993.Bayers, Chip. "The Original Internet Adman", AdWeek, 2011-07-12. Retrieved on 1-17-12. The firm developed the software product that became the web analytics company Accrue. The firm completed an initial public offering in February 2000 under the ticker OGNC,Koffey, Nicole. "Organic (OGNC) to Open Strong", Forbes, 2000-02-02. Retrieved on 2009-07-03. but like many dot-com companies, was adversely affected when the Dot-com bubble burst and drastically reduced its size. It was re-privatized in 2001, and in 2003, became a wholly owned subsidiary of advertising holding company Omnicom Group.Mack, Ann M. "Omnicom Confirms Organic Purchase", AdWeek, 2003-03-03. Retrieved on 2009-07-03. Marketing Intelligence The firm uses a proprietary set of analytics tools to forecast future sales.Steel, Emily. "Modeling Tools Stretch Ad Dollars", Wall Street Journal, 2009-5-18. Retrieved 1-17-2012.Schwartz, Evan. "A New Model for Predicting Social-Media Impact", MIT Technology Review, Published by MIT, 2010-10-20. Retrieved on 1-17-2012.O’Leary, Noreen. "Media All-Star: Steve Kerho", AdWeek, 2011-11-19. Retrieved on 1-17-2012. One client of this service was Chrysler.Klaassen, Abbey. "Interactive Agency Organic Predicts Chrysler Sales With Media-Mix ROI Model", Ad Age, 2009-3-23. Retrieved on 1-17-2012. Notable work Among its notable work was their launch, in the spring of 2010, of the “Break the Cycle” campaign, a CPG launch for the "U by Kotex" brand built around social media.Neff, Jack. "Comparative Claims Resurface in Tampon Wars", AdAge, 2011-7-25. Retrieved on 1-17-2012. The firm also did work with The Meth ProjectNudd, Tim. "Darren Aronofsky Revisits the Horrors of Addiction in Anti-Meth PSAs", Adweek, 2011-11-8. Retrieved on 1-17-2012. which included TV, radio, out-of-home, social and digital components, including an immersive online experience at www.MethProject.org in an effort to counter meth addiction. References External links *Company Website Digital marketing companies of the United States Companies based in San Francisco Marketing companies established in 1993 "
"So Long Mr. Chumps is a 1941 short subject directed by Jules White starring American slapstick comedy team The Three Stooges (Moe Howard, Larry Fine and Curly Howard). It is the 53rd entry in the series released by Columbia Pictures starring the comedians, who released 190 shorts for the studio between 1934 and 1959. Plot The Stooges are inept but honest street cleaners. When they come across an envelope filled with oil bonds in the trash, they return them to their owner, B.O. Davis (John Tyrrell). The grateful Davis offers them a five thousand dollar reward if they can find an honest man with executive abilities. An honest dog ultimately leads them to a weeping girl (Dorothy Appleby), who explains that her sweetheart has been unfairly jailed. The best way to talk to him, the Stooges figure, is to get arrested themselves. They land in the clink and track down their man, Percy Pomeroy (Eddie Laughton). With some black paint, they make their prison outfits look like guard uniforms and make their escape. Just as they are leaving, Davis is coming in — handcuffed to a detective and revealed as "Lone Wolf Louie, the biggest bond swindler in America." The Stooges wind up back in jail, breaking rocks over Curly's head. Cast Credited Production notes So Long Mr. Chumps was filmed on July 25–30, 1940. The film title is a parody of the film Goodbye, Mr. Chips. The jail sequences were reused in Beer Barrel Polecats. When the Stooges drop their iron balls that are chained to their legs, the sounds that are heard are again the NBC Chimes, a gag recycled from the team's 1937 short Back to the Woods. Bud Jamison appeared in a deleted scene where he was a policeman noticing the Stooges and Pomeroy's girlfriend. In the final scene, where Moe and Larry were breaking rocks over Curly's head, Larry picks up what seems to be a rather heavy rock. Curly notices the rock and replies, "Hey, wait a minute! That's a real one! I'm no fool." Curly then chuckles, while Larry and Moe smile. Often regarded as an unscripted moment, it was later determined that exchange was scripted in advance, as it appeared in director Jules White's final shooting script. Bruce Bennett (aka Herman Brix, a former Olympic athlete and Tarzan actor) appears in dual roles as both a truck driver and as one of the guards giving orders to the Stooges. Laurel and Hardy had painted their prison uniforms white in 1927's The Second Hundred Years. They were also trash collectors in 1939's A Chump at Oxford. References External links So Long Mr. Chumps at threestooges.net 1941 films The Three Stooges films American films English-language films American black-and-white films Films directed by Jules White Columbia Pictures short films American slapstick comedy films 1941 comedy films "
"In enzymology, an aminoacyl-tRNA hydrolase () is an enzyme that catalyzes the chemical reaction :N-Substituted aminoacyl-tRNA + H2O \rightleftharpoons N-substituted amino acid + tRNA Thus, the two substrates of this enzyme are N-Substituted aminoacyl-tRNA and H2O, whereas its two products are N-substituted amino acid and tRNA. This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is aminoacyl-tRNA aminoacylhydrolase. Other names in common use include aminoacyl-transfer ribonucleate hydrolase, N-substituted aminoacyl transfer RNA hydrolase, and peptidyl-tRNA hydrolase. Structural studies As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , and . References * EC 3.1.1 Enzymes of known structure "